BioTech Mag Search: DNA
Insights into Modular Polyketide Synthase Loops Aided by Repetitive Sequences
ABSTRACT The loops of modular polyketide synthases serve diverse functions but are largely uncharacterized. They frequently contain amino acid repeats resulting from genetic...
1 minute ago - Wiley
Researchers call for greater awareness of unintended consequences of CRISPR gene editing
Researchers at the Francis Crick Institute have revealed that CRISPR-Cas9 genome editing can lead to unintended mutations at the targeted section of DNA in early human embryos...
16 hours ago - Phys
What is mRNA? What you should know about the key ingredient in some COVID-19 vaccines
One surprising star of the coronavirus pandemic response has been the molecule called mRNA. It's the key ingredient in the Pfizer and Moderna COVID-19 vaccines. But mRNA itself...
16 hours ago - Phys
Technique allows mapping of epigenetic information in single cells at scale
Histones are tiny proteins that bind to DNA and hold information that can help turn on or off individual genes. Researchers at Karolinska Institutet have developed a technique...
16 hours ago - Phys
Epigenetic Regulation of Gut Microbial Dysbiosis
Abstract Microbiota inside the gut plays a vital role in maintaining human health. Microbial dysbiosis is associated with various complications leading to a range of diseases...
1 day ago - Springer
Boundless Bio Presents Data on the Role of Extrachromosomal DNA in Mediating Resistance to Targeted Therapies at the American Association for Cancer Research Annual Meeting 2021
SAN DIEGO--Boundless Bio, a next-generation precision oncology company developing innovative therapeutics directed against extrachromosomal DNA in aggressive cancers, today...
2 days ago - San Diego Biotechnology - 2 articles
MIT and UCSF researchers create CRISPR ‘on-off switch' that controls gene expression without changing DNA
MIT and UCSF researchers create CRISPR ‘on-off switch' that controls gene expression without changing DNA arlene.weintraub Thu, 04/08/2021 - 08:48
3 days ago - Fierce Biotech
DNA methylation regulator QSER1 identified
A team of researchers from a number of institutions in the U.S. has identified a DNA methylation regulator called QSER1. In their paper published in the journal Science, the...
3 days ago - Phys
New, reversible CRISPR method can control gene expression while leaving underlying DNA sequence unchanged
Over the past decade, the CRISPR-Cas9 gene editing system has revolutionized genetic engineering, allowing scientists to make targeted changes to organisms' DNA. While the...
3 days ago - Phys - 2 articles
Scientists discover 'jumping' genes that can protect against blood cancers
New research has uncovered a surprising role for so-called 'jumping' genes that are a source of genetic mutations responsible for a number of human diseases. Scientists made...
3 days ago - ScienceDaily - 2 articles
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2nd International Conference on Generic Drugs and Biosimilars
2nd International Conference on Generic Drugs and Biosimilars
2nd International Conference on Generic Drugs and Biosimilars
2nd International Conference on Generic Drugs and Biosimilars
Colored Network Motif Analysis by Dynamic Programming Approach: An...
Network motifs are subgraphs of a network which are found with significantly higher frequency than that expected in similar random networks. Motifs are small building blocks of...
Improve the Resolution and Parallel Performance of the Three-Dimensional...
In cryo-electron microscopy, RELION is a powerful tool for high-resolution reconstruction. Due to the complicated imaging procedure and the heterogeneity of particles, some of...
IPhosH-PseAAC: Identify Phosphohistidine Sites in Proteins by Blending...
Protein phosphorylation is one of the key mechanism in prokaryotes and eukaryotes and is responsible for various biological functions such as protein degradation, intracellular...
MCHMDA:Predicting Microbe-Disease Associations Based on Similarities and...
With the development of high-through sequencing technology and microbiology, many studies have evidenced that microbes are associated with human diseases, such as obesity...
MGRFE: Multilayer Recursive Feature Elimination Based on an Embedded Genetic...
Microarray gene expression data have become a topic of great interest for cancer classification and for further research in the field of bioinformatics. Nonetheless, due to the...
ANCA: Alignment-Based Network Construction Algorithm
Dynamic biological networks model changes in the network topology over time. However, often the topologies of these networks are not available at specific time points. Existing...
Bayesian Inference in Y-Linked Two-Sex Branching Processes with Mutations...
A Y-linked two-sex branching process with mutations and blind choice of males is a suitable model for analyzing the evolution of the number of carriers of a Y-linked allele and...
CNV IFTV: An Isolation Forest and Total Variation-Based Detection of CNVs...
Accurate detection of copy number variations from short-read sequencing data is challenging due to the uneven distribution of reads and the unbalanced amplitudes of gains and...
Vaccines: Herd Immunity, Passports, Reaching the Underserved
As the COVID-19 vaccinations roll out with increasing speed, questions are now arising about herd immunity, the need to reach underserved populations, and a proposed passport...
Computational methods for chromosome-scale haplotype reconstruction
High-quality chromosome-scale haplotype sequences of diploid genomes, polyploid genomes, and metagenomes provide important insights into genetic variation associated with...