BioTech Mag Search: Therapies
Phase I study of opaganib, an oral sphingosine kinase 2-specific inhibitor, in relapsed and/or refractory multiple myeloma
Abstract Multiple myeloma remains an incurable disease and there is an unmet medical need for novel therapeutic drugs that do not share similar mechanisms of action with...
6 hours ago - Springer
Micronome Revealed miR-205-5p as Key Regulator of VEGFA During Cancer Related Angiogenesis in Hepatocellular Carcinoma
Abstract The high ratio of global mortality rate to incidence rate and steep increase in incidence of liver cancer warrants need for advancement of innovative cancer treatment...
6 hours ago - Springer
The ChaC1 active site: Defining the residues and determining the role of ChaC1‐exclusive residues in the structural and functional stability
Abstract The glutathione degrading enzyme ChaC1 is highly upregulated in several cancers and viral infections making it a potential pharmacological target for cancer therapy...
20 hours ago - Wiley
Mirati Therapeutics Announces Update for the Phase 3 SAPPHIRE Study
Evaluating Investigational Sitravatinib in Combination with Nivolumab for Patients with Non-Squamous Non-Small Cell Lung Cancer with Acquired Resistance to Chemotherapy and...
21 hours ago - San Diego Biotechnology
Scientists Receive $4.8M to Pursue Gene Therapy for ‘Incurable' Disease
The California Institute for Regenerative Medicine has awarded UC San Diego researchers $4.8 million to advance a gene therapy to treat Friedreich's ataxia, a rare but...
1 day ago - San Diego Biotechnology
UFGI Publication Round-up: Week of 11/28/22
PROTAC therapy as a new targeted therapy for lung cancer. Li JW, Zheng G, Kaye FJ, Wu L. Mol Ther. 2022 Nov 21:S1525-0016(22)00669-4. doi: 10.1016/j.ymthe.2022.11.011. Online...
2 days ago - Genetics Institute - 2 articles
FDA Approves First Gene Therapy for Hemophilia B
Posted on: 29 November 2022, The FDA has approved etranacogene dezaparvovec for the treatment of adults with Hemophilia B who are currently using Factor IX prophylaxis...
3 days ago - Gene Therapy
Oxygen‐Insensitive Nitroreductase E. coli NfsA, but not NfsB, is inhibited by fumarate
Abstract E. coli NfsA and NfsB are founding members of two flavoprotein families that catalyse the oxygen-insensitive reduction of nitroaromatics and quinones by NADH. This...
3 days ago - Wiley
Turnstone Biologics Enters Cooperative Research and Development Agreement with the National Cancer Institute to Study TIL Therapy in Combination with Viral Immunotherapy
SAN DIEGO-- NCI-Collaboration focused on potentiating the clinical benefit of TIL therapy against solid tumors through novel combinations with viral immunotherapy
3 days ago - San Diego Biotechnology
Treating Transthyretin Amyloidosis via Adeno-Associated Virus Vector Delivery of Meganucleases
Greig, JA. et al. Human Gene Therapy. 1174-1186 (2022).
4 days ago - Precision Biosciences
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2nd International Conference on Generic Drugs and Biosimilars
2nd International Conference on Generic Drugs and Biosimilars
2nd International Conference on Generic Drugs and Biosimilars
2nd International Conference on Generic Drugs and Biosimilars
Quality Control Manager - Elite ProTek - La Jolla, CA
The QC manager is responsible for setting and overseeing the objectives of the quality control group, serving as technical lead for method development,... $130,000 - $140,000 a...
Sr Research Associate - Roche - Carlsbad, CA
Experience with experimental design, setup, data collection and analysis. EPlex streamlines the diagnostic workflow from physician order entry to the...
Phase I study of opaganib, an oral sphingosine kinase 2-specific inhibitor...
Abstract Multiple myeloma remains an incurable disease and there is an unmet medical need for novel therapeutic drugs that do not share similar mechanisms of action with...
The association of accelerated epigenetic age with all-cause mortality in...
Abstract Background Epigenetic age is a DNA methylation-based biomarker of aging that is accurate across the lifespan and a range of cell types. The difference between...
Characterization of tomato leaf curl Palampur virus naturally infecting wild...
Abstract Weeds plants serve as a reservoir of begomoviruses Begomovirus and play a vital role in the diversity of single stranded DNA viruses. Wild melon plants showing leaf...
Micronome Revealed miR-205-5p as Key Regulator of VEGFA During Cancer...
Abstract The high ratio of global mortality rate to incidence rate and steep increase in incidence of liver cancer warrants need for advancement of innovative cancer treatment...
Assessing the relative performance of fast molecular dating methods for...
Abstract Advances in genome sequencing techniques produced a significant growth of phylogenomic datasets. This massive amount of data represents a computational challenge for...
Identification of chromosomal type II toxin-antitoxin system from plant...
Abstract Backgrounds Almost all bacteria harbor toxin-antitoxin systems on their chromosomes, which are associated with diverse biological roles such as stress response, cell...
OIP5-AS1 Inhibits Oxidative Stress and Inflammation in Ischemic Stroke...
Abstract Background: Ischemic stroke is a very dangerous disease with high incidence, fatality and disability rate in human beings. Massive evidence has indicated that...
Legacy effects of fumigation on soil bacterial and fungal communities and...
Abstract Background Soil microorganisms are integral to maintaining soil health and crop productivity, but fumigation used to suppress soilborne diseases may affect soil...