• Tuning Monoclonal Antibody Galactosylation using Raman Spectroscopy‐Controlled Lactic Acid Feeding

    1 month ago - By Wiley

    Abstract
    A key aspect of large‐scale production of biotherapeutics is a well‐designed and consistently‐executed upstream cell culture process. Process Analytical Technology tools provide enhanced monitoring and control capabilities to support consistent process execution, and also have potential to aid in maintenance of product quality at desired levels. One such tool, Raman spectroscopy, has matured as a useful technique to achieve real‐time monitoring and control of key cell culture process attributes. We developed a Raman spectroscopy‐based nutrient control strategy to enable dual...
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