BioTech Mag Search: Antibiotics
Insight into Substrate‐assisted Catalytic Mechanism and Stereoselectivity of Bifunctional Nocardicin Thioesterase
27 days ago - By Wiley
Abstract
The inversion from L- to D-stereochemistry endows peptides improved bioactivity and enhanced resistance to many proteases and peptidases. To strengthen the biostability and bioavailability of peptide drugs, enzymatic epimerization becomes an important way to incorporate D-amino acid into peptide backbones. Recently, a bifunctional thioesterase NocTE, which is responsible for the epimerization and hydrolysis of the C-terminal glycine residue of β-lactam antibiotic nocardicin A, exclusively directs to the generation of D-diastereomers. Different from other epimerases, NocTE exhibits...
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2nd International Conference on Generic Drugs and Biosimilars
2nd International Conference on Generic Drugs and Biosimilars
2nd International Conference on Generic Drugs and Biosimilars
2nd International Conference on Generic Drugs and Biosimilars
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Staff Scientist, Technical Operations - Thermo Fisher Scientific - Carlsbad, CA
BS degree, plus five (5) or MS/PhD three (3) years relevant manufacturing experience, or equivalent combination of education and experience...
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