• Model‐based workflow for scale‐up of process strategies developed in miniaturized bioreactor systems

    6 days ago - By Wiley

    Abstract
    Miniaturized Bioreactor Systems are routinely used in the development of mammalian cell culture processes. However, scale‐up of process strategies obtained in MBR‐ to larger scale is challenging due to mainly non‐holistic scale‐up approaches. In this study, a model‐based workflow is introduced to quantify differences in the process dynamics between bioreactor scales and thus enable a more knowledge‐driven scale‐up. The workflow is applied to two case studies with antibody‐producing Chinese hamster ovary cell lines. With the workflow, model parameter distributions are estimated...
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