• Biochemical and clinical studies of putative allergens to assess what distinguishes them from other non-allergenic proteins in the same family

    13 days ago - By Springer

    Abstract
    Many protein families have numerous members listed in databases as allergens; however, some allergen database entries, herein called “orphan allergens”, are members of large families of which all other members are not allergens. These orphan allergens provide an opportunity to assess whether specific structural features render a protein allergenic. Three orphan allergens [ Cladosporium herbarum aldehyde dehydrogenase , Alternaria alternata ALDH , and C. herbarum mannitol dehydrogenase ] were recombinantly produced and purified for structure characterization and for clinical skin...
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