• CircSTAM inhibits migration and invasion of trophoblast cells by regulating miR-148a-5p/PTEN axis

    1 month ago - By Springer

    Abstract
    Background
    The mechanisms underlying the pathogenesis of preeclampsia remains unclear. Exploring the molecular players in PE progression can provide insights into targeted therapy.
    Methods
    The expression levels of circSTAM in placental chorionic tissues of PE patients and normal pregnant women were compared by RT-qPCR. CircSTAM was knocked down by small interfering RNA to investigate its role in migration, invasion and epithelial-mesenchymal transformation of trophoblast HTR-8/SVneo cells. The downstream target of circSTAM was predicted using online bioinformatics resources, and...
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