• Troponin C-1 Activated by E2F1 Accelerates Gastric Cancer Progression via Regulating TGF-β/Smad Signaling

    9 days ago - By Springer

    Abstract
    Background
    Troponin C-1 has been previously characterized as an oncogenic gene.
    Aims
    This study aimed to reveal the roles of TNNC1 in gastric cancer and the potential underlying mechanisms.
    Methods
    TNNC1 siRNAs and TNNC1 overexpression plasmid were used to alter its expression in AGS, MKN45, and HGC-27 cells. CCK-8 assay, colony formation, EdU assay, flow cytometry, transwell assay, and scratch test were conducted to measure the phenotype changes. In vivo effects of TNNC1 silence were confirmed by using a xenograft mouse model. Bioinformatics analysis was conducted to screen out...
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