• A Circular RNA, hsa circ 0018180 , Triggers Glycolysis and Promotes Malignancy of Head and Neck Squamous Cell Carcinoma Through the miR-5194/ENO1 Axis

    6 days ago - By Springer

    Abstract
    Emerging evidence has demonstrated the pivotal roles of circular RNAs in the modulation of malignancy and pathological progression among multiple human cancers. Glucose metabolism reprogramming is a widely identified characteristic for contributing to facilitate tumorigenesis. Nonetheless, their contributions to head and neck squamous cell carcinoma cell glycolysis remain to be further elucidated. Herein, we aim to investigate the role of circRNA, hsa circ 0018180 in HNSCC. Expression patterns of circPARD3 in HNSCC tissues and different cell lines were determined by qRT-PCR assay...
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  • CircRNA-PTPRA Knockdown Inhibits Atherosclerosis Progression by Repressing ox-LDL-Induced Endothelial Cell Injury via Sponging of miR-671-5p

    6 days ago - By Springer

    Abstract
    Atherosclerosis is a chronic inflammatory disease with high morbidity and mortality rates worldwide. This study aimed to investigate the role of circular RNA protein tyrosine phosphatase receptor type A in oxidized low-density lipoprotein -induced human umbilical vein endothelial cell injury and its underlying molecular mechanism. The expression of circRNA-PTPRA and microRNA -671-5p was assessed by quantitative reverse transcription PCR. The interaction between circRNA-PTPRA and miR-671-5p was predicted using bioinformatic analysis. Cell viability and apoptosis were determined...
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