• The Epigenetic Pacemaker: modeling epigenetic states under an evolutionary framework

    14 days ago - By Oxford Journals

    AbstractSummaryEpigenetic rates of change, much as evolutionary mutation rate along a lineage, vary during lifetime. Accurate estimation of the epigenetic state has vast medical and biological implications. To account for these non-linear epigenetic changes with age, we recently developed a formalism inspired by the Pacemaker model of evolution that accounts for varying rates of mutations with time. Here, we present a python implementation of the Epigenetic Pacemaker , a conditional expectation maximization algorithm that estimates epigenetic landscapes and the state of individuals and may...
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