• Cancer subtype classification and modeling by pathway attention and propagation

    6 days ago - By Oxford Journals

    AbstractMotivationBiological pathway is important curated knowledge of biological processes. Thus, cancer subtype classification based on pathways will be very useful to understand differences in biological mechanisms among cancer subtypes. However, pathways include only a fraction of the entire gene set, only 1/3 of human genes in KEGG, and pathways are fragmented. For this reason, there are few computational methods to use pathways for cancer subtype classification.ResultsWe present an explainable deep learning model with attention mechanism and network propagation for cancer subtype...
    Read more ...