• Identifying signaling genes in spatial single cell expression data

    19 days ago - By Oxford Journals

    AbstractMotivationRecent technological advances enable the profiling of spatial single cell expression data. Such data presents a unique opportunity to study cell-cell interactions and the signaling genes that mediate them. However, most current methods for the analysis of this data focus on unsupervised descriptive modeling, making it hard to identify key signaling genes and quantitatively assess their impact.ResultsWe developed a M ixture of E xperts for S patial S ignaling genes I dentification method to identify active signaling genes within and between cells. The mixture of experts...
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