• MOOMIN - Mathematical explOration of 'Omics data on a MetabolIc Network

    8 monthes ago - By Oxford Journals

    AbstractMotivationAnalysis of differential expression of genes is often performed to understand how the metabolic activity of an organism is impacted by a perturbation. However, because the system of metabolic regulation is complex and all changes are not directly reflected in the expression levels, interpreting these data can be difficult.ResultsIn this work, we present a new algorithm and computational tool that uses a genome-scale metabolic reconstruction to infer metabolic changes from differential expression data. Using the framework of constraint-based analysis, our method produces a...
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