• Transcriptional processing of an unnatural base pair by eukaryotic RNA polymerase II

    3 monthes ago - By ACS Division of Biological Chemistry

    Nature Chemical Biology, Published online: 17 June 2021; doi:10.1038/s41589-021-00817-3 Structural biology, computational biology and biochemical analysis revealed the molecular mechanism of transcriptional processing of unnatural base pairs selectively recognized by cellular RNA polymerase.
    Read more ...

     

  • Fighting PRC1 via the RING

    3 monthes ago - By ACS Division of Biological Chemistry

    Nature Chemical Biology, Published online: 21 June 2021; doi:10.1038/s41589-021-00819-1 Over the past two decades, inhibitors of the polycomb repressor complex have been driven from bench to bedside. New chemical compounds targeting the RING1B in polycomb repressor complex 1 add important tools to regulate polycomb functions.
    Read more ...

     

  • Predictable control of RNA lifetime using engineered degradation-tuning RNAs

    3 monthes ago - By ACS Division of Biological Chemistry

    Nature Chemical Biology, Published online: 21 June 2021; doi:10.1038/s41589-021-00816-4 Degradation-tuning RNAs have the capacity to increase and decrease RNA stability in vivo and in vitro. Appending these modules to transcripts allows fine tuning of circuit dynamics, CRISPR interference and paper-based viral diagnostics.
    Read more ...

     

  • Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain

    3 monthes ago - By ACS Division of Biological Chemistry

    Nature Chemical Biology, Published online: 21 June 2021; doi:10.1038/s41589-021-00815-5 Fragment screening and medicinal chemistry optimization led to development of a small-molecule inhibitor of RING1B-BMI1 E3 ligase, blocking the H2A ubiquitination activity of the Polycomb repressive complex 1 and inducing differentiation in leukemia cells.
    Read more ...