• Engineering tumor constructs to study matrix‐dependent angiogenic signaling of breast cancer cells

    29 days ago - By Wiley

    Abstract
    Breast cancer is the leading cause of cancer deaths among females globally. The crosstalk between tumor microenvironment and neoplastic cells is the key for promoting tumor growth, stimulating tumor angiogenesis, and metastasis to distant organs. Thus, it is highly important to investigate tumor cell-matrix interactions to facilitate screening of different anti-cancer agents, individually or in combination. We, herein report, the development of an in vitro three-dimensional breast cancer model to investigate the effect of stromal crosslinking and consequent, stiffening on the...
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  • A novel NCI‐H69V small cell lung cancer functional mini‐tumor model for future treatment screening applications

    29 days ago - By Wiley

    Abstract
    Small cell lung cancer is aggressive and despite multiple clinical trials, its standard of care is unchanged for the past three decades. In vitro cancer models are crucial in chemotherapy development, and three-dimensional models aim to bridge the gap between two-dimensional flat cultures and in vivo testing. Functional 3D spheroids can better represent the in vivo situation and tumor characteristics than 2D models. An NCI-H69V SCLC mini-tumor model was developed in a clinostat-based rotating bioreactor system. Spheroid growth and viability were characterized for 30 days, and the...
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