• Genome-wide differential expression profiling of lncRNAs and mRNAs in human induced pluripotent stem cell-derived endothelial cells exposed to e-cigarette extract

    1 month ago - By Springer

    Abstract
    Background
    Electronic-cigarette usage, particularly in the youth population, is a growing concern. It is known that e-cig causes endothelial dysfunction, which is a risk factor for the development of cardiovascular diseases; however, the mechanisms involved remain unclear. We hypothesized that long noncoding RNAs may play a role in e-cig-induced endothelial dysfunction.
    Methods
    Here, we identified lncRNAs that are dysregulated in human induced pluripotent stem cell-derived endothelial cells following 24 h of e-cig aerosol extract treatment via microarray analysis. We performed...
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