• Dimerization underlies the aggregation propensity of intrinsically disordered coiled‐coil domain‐containing 124

    14 days ago - By Wiley

    Abstract
    Coiled-coil domain-containing 124 is a recently discovered ribosome-binding protein conserved in eukaryotes. CCDC124 has regulatory functions on the mediation of reversible ribosomal hibernation and translational recovery by direct attachment to large subunit ribosomal protein uL5, 25S rRNA backbone, and tRNA-binding P/A-site major groove. Moreover, it independently mediates cell division and cellular stress response by facilitating cytokinetic abscission and disulfide stress-dependent transcriptional regulation, respectively. However, the structural characterization and...
    Read more ...