• A deep learning approach to evaluate the feasibility of enzymatic reactions generated by retrobiosynthesis

    18 days ago - By Wiley

    Abstract
    Retrobiosynthesis allows the designing of novel biosynthetic pathways for the production of chemicals and materials through metabolic engineering but generates a large number of reactions beyond the experimental feasibility. Thus, an effective method that can reduce a large number of the initially predicted enzymatic reactions has been needed. Here, we present a deep learning‐based reaction feasibility checker named DeepRFC to classify the feasibility of a given enzymatic reaction with high performance and speed. DeepRFC is designed to receive Simplified Molecular‐Input Line‐Entry...
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