• Crossing boundaries

    10 days ago - By ACS Division of Biological Chemistry

    Nature Chemical Biology, Published online: 26 April 2021; doi:10.1038/s41589-021-00795-6 Crossing boundaries
    Read more ...

     

  • Designing stable DNAzymes

    10 days ago - By ACS Division of Biological Chemistry

    Nature Chemical Biology, Published online: 26 April 2021; doi:10.1038/s41589-021-00796-5 Designing stable DNAzymes
    Read more ...

     

  • Guiding light

    10 days ago - By ACS Division of Biological Chemistry

    Nature Chemical Biology, Published online: 26 April 2021; doi:10.1038/s41589-021-00794-7 Guiding light
    Read more ...

     

  • Focal assembly

    10 days ago - By ACS Division of Biological Chemistry

    Nature Chemical Biology, Published online: 26 April 2021; doi:10.1038/s41589-021-00797-4 Focal assembly
    Read more ...

     

  • Engineering AraC to make it responsive to light instead of arabinose

    10 days ago - By ACS Division of Biological Chemistry

    Nature Chemical Biology, Published online: 26 April 2021; doi:10.1038/s41589-021-00787-6 Engineering of a blue light-inducible AraC dimerization system in E. coli permits light-dependent, rather than arabinose-based, regulation of gene expression from standard PBAD promoters, enabling temporal and spatial control of bacterial systems.
    Read more ...

     

  • A stop sign for RAS trafficking

    10 days ago - By ACS Division of Biological Chemistry

    Nature Chemical Biology, Published online: 29 April 2021; doi:10.1038/s41589-021-00789-4 N-Ras lipidation cycling is known to regulate its trafficking and function. A new S-depalmitoylation inhibitor induces N-Ras membrane mislocalization, providing insights into N-Ras function and laying the foundation for a new cancer therapeutic strategy.
    Read more ...

     

  • ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth

    10 days ago - By ACS Division of Biological Chemistry

    Nature Chemical Biology, Published online: 29 April 2021; doi:10.1038/s41589-021-00785-8 ABD957 is a potent and selective inhibitor of the ABHD17 family of depalmitoylases that disrupts N-Ras signaling in human acute myeloid leukemia cells and can synergize with MEK inhibition.
    Read more ...