• Organelle membrane-specific chemical labeling and dynamic imaging in living cells

    1 month ago - By ACS Division of Biological Chemistry

    Nature Chemical Biology, Published online: 21 September 2020; doi:10.1038/s41589-020-00651-z Imaging of phosphatidylcholine, sphingomyelin and their interorganelle lipid transport in live cells, using azido-choline and a spatially limited bioorthogonal tag, suggests that autophagosomal membranes originate from the ER.
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  • ARID2 is a pomalidomide-dependent CRL4 CRBN substrate in multiple myeloma cells

    1 month ago - By ACS Division of Biological Chemistry

    Nature Chemical Biology, Published online: 21 September 2020; doi:10.1038/s41589-020-0645-3 Immunomodulatory drugs are used for the treatment of multiple myeloma. ARID2, a component of the PBAF chromatin-remodeling complex, is a new pomalidomide-induced neosubstrate of CRL4CRBN, which accounts for its superior efficacy over lenalidomide.
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