• CHESPA/CHESCA-SPARKY: automated NMR data analysis plugins for SPARKY to map protein allostery

    10 days ago - By Oxford Journals

    AbstractMotivationCorrelated NMR chemical shift changes identified through the CHEmical Shift Projection Analysis and CHEmical Shift Covariance Analysis reveal pathways of allosteric transitions in biological macromolecules. To address the need for an automated platform that implements CHESPA and CHESCA and integrates them with other NMR analysis software packages, we introduce here integrated plugins for NMRFAM-SPARKY that implement the seamless detection and visualization of allosteric networks.AvailabilityCHESCA-SPARKY and CHESPA-SPARKY are available in the latest version of...
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