• E-MAGMA: an eQTL-informed method to identify risk genes using genome-wide association study summary statistics

    22 days ago - By Oxford Journals

    AbstractMotivationGenome-wide association studies have successfully identified multiple independent genetic loci that harbour variants associated with human traits and diseases, but the exact causal genes are largely unknown. Common genetic risk variants are enriched in non-protein-coding regions of the genome and often affect gene expression in a tissue-specific manner. To address this challenge, we developed a methodological framework, E-MAGMA, which converts genome-wide association summary statistics into gene-level statistics by assigning risk variants to their putative genes based on...
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  • Resequencing of 301 ramie accessions identifies genetic loci and breeding selection for fiber yield traits

    22 days ago - By Wiley

    Summary
    Ramie is an important fiber-producing crop in China; however, the genetic basis of its agronomic traits remains poorly understood. We produced a comprehensive map of genomic variation in ramie based on resequencing of 301 landraces and cultivars. Genetic analysis produced 129 signals significantly associated with six fiber yield-related traits, and several genes were identified as candidate genes for respective traits. Furthermore, we found that natural variations in the promoter region of Bnt14G019616 were associated with extremely low fiber abundance, providing the first evidence...
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