• Plastic structures for diverse substrates: a revisit of human ABC transporters

    9 days ago - By Wiley

    Abstract
    ATP-binding cassette superfamily is one of the largest groups of primary active transporters that could be found in all kingdoms of life from bacteria to humans. In human, ABC transporters can selectively transport a wide spectrum of substrates across membranes, thus playing a pivotal role in multiple physiological processes. In addition, due to the ability of exporting clinic therapeuticals, some ABC transporters were originally termed multidrug resistance proteins. Increasing investigations of human ABC transporters in recent years have provided abundant information for...
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