• Why are ACE2 binding coronavirus strains SARS‐CoV/SARS‐CoV‐2 wild and NL63 mild?

    10 days ago - By Wiley

    ABSTRACT
    Coronaviruses are responsible for several epidemics, including the 2002 SARS, 2012 MERS and COVID‐19. The emergence of recent COVID‐19 pandemic due to SARS‐CoV‐2 virus in December 2019 has resulted in considerable research efforts to design antiviral drugs and other therapeutics against coronaviruses. In this context, it is crucial to understand the biophysical and structural features of the major proteins that are involved in virus‐host interactions. In the current study, we have compared spike proteins from three strains of coronaviruses NL63, SARS‐CoV and SARS‐CoV, known to...
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  • Biophysical analysis of SARS‐CoV‐2 transmission and theranostic development via N protein computational characterization

    10 days ago - By Wiley

    Abstract
    Recently, SARS‐CoV‐2 has been identified as the causative factor of viral infection called COVID‐19 that belongs to the zoonotic beta coronavirus family known to cause respiratory disorders or viral pneumonia, followed by an extensive attack on organs that express angiotensin‐converting enzyme II. Human transmission of this virus occurs via respiratory droplets from symptomatic and asymptomatic patients, which are released into the environment after sneezing or coughing. These droplets are capable of staying in the air as aerosols or surfaces and can be transmitted to persons...
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