• Gene-set integrative analysis of multi-omics data using tensor-based association test

    22 days ago - By Oxford Journals

    AbstractMotivationFacilitated by technological advances and the decrease in costs, it is feasible to gather subject data from several omics platforms. Each platform assesses different molecular events, and the challenge lies in efficiently analyzing these data to discover novel disease genes or mechanisms. A common strategy is to regress the outcomes on all omics variables in a gene set. However, this approach suffers from problems associated with high-dimensional inference.ResultsWe introduce a tensor-based framework for variable-wise inference in multi-omics analysis. By accounting for...
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  • GAMUT: A genomics big data management tool

    22 days ago - By Journal of Biosciences

    Abstract
    Efficient analysis of Single Nucleotide Polymorphisms across genomic samples enable in deciphering the relationship between genotype and phenotype. The core principle behind SNP comparison is to arrive at a probable list of variants that can differentiate two sets of data. Such SNPs have direct applications in array design, genotype imputation and in cataloging of variants in regions of interest. We have developed GAMUT , a big data-based solution for efficient run-time comparison of SNPs across large datasets based on partition of samples belonging to different populations taking...
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  • The Importance of Validation

    The Importance of Validation

    22 days ago - By PSC Biotech

    Validation is the collection and evaluation of data, from the process design stage through production, which establishes scientific evidence that a process and or device can consistently deliver a quality product. Process validation involves a series of activities taking place over the lifecycle of the product and process. Creating a Validation Master Plan is a guide for successful validation and qualification throughout a facility.
    To ensure that a specific piece of equipment or process gives the output desired, the equipment used for the product must be validated. Equipment used for...
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  • Taxonomy-based data representation for data mining: an example of the magnitude of risk associated with H. pylori infection

    22 days ago - By BioData Mining

    The amount of available and potentially significant data describing study subjects is ever growing with the introduction and integration of different registries and data banks. The single specific attribute of...
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  • Evaluation of different approaches for missing data imputation on features associated to genomic data

    22 days ago - By BioData Mining

    Missing data is a common issue in different fields, such as electronics, image processing, medical records and genomics. They can limit or even bias the posterior analysis. The data collection process can lead...
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