BioTech Mag Search: Therapies
Electroconvulsive Stimulation in Rats Induces Alterations in the Hippocampal miRNome: Translational Implications for Depression
1 month ago - By Springer
Abstract
MicroRNAs may contribute to the development of depression and its treatment. Here, we used the hypothesis-neutral approach of next-generation sequencing to gain comprehensive understanding of the effects of a course of electroconvulsive stimulation , the animal model equivalent of electroconvulsive therapy , on rat hippocampal miRNAs. Significant differential expression ( p
Read more ...An internal pilot study of a novel rectal mucocellular sampling device to allow next-generation sequencing for colorectal disease
1 month ago - By Springer
Abstract
Background
The ORI-EGI-02 study was designed to test the hypothesis that rectal mucus collected using a novel rectal sampling device , contains sufficient human deoxyribonucleic acid of the required quality for Next Generation Sequencing , for colorectal disease genetic signature discovery.
Methods
Using National Institute for Health and Care Research methodology, an internal pilot study was performed in January 2020-May 2021, at four sites in the United Kingdom, to assess the process of recruitment, consent, specimen acquisition and viability for analysis. Following an OriCol ™...
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2nd International Conference on Generic Drugs and Biosimilars
2nd International Conference on Generic Drugs and Biosimilars
2nd International Conference on Generic Drugs and Biosimilars
2nd International Conference on Generic Drugs and Biosimilars
Research Assistant I - Genomic Analysis Laboratory - Salk Institute for...
Other duties include general laboratory maintenance, coordination with collaborators and FACS core for cell sorting, participation in regular team meetings...
Microbiome differences in sugarcane and metabolically engineered oilcane...
Oilcane is a metabolically engineered sugarcane that hyper-accumulates lipids in its vegetable biomass to provide an advanced feedstock for biodiesel production. The potential...
Degradation of lignin in different lignocellulosic biomass by steam...
The difficulty of degrading lignin is the main factor limiting the high-value conversion process of lignocellulosic biomass. The biodegradation of lignin has attracted much...
Study suggests chromosomal errors may hinder some aggressive tumors
Chromosomal errors are a hallmark of cancer cells. Defects in the genome derived from the incorrect separation of chromosomes in each division of cells drive tumor growth and...
Genetically engineered CXCR4-modified exosomes for delivery of miR-126...
Biofilm-related diseases are a group of diseases that tolerate antimicrobial chemotherapies and therefore are refractory to treatment. Periodontitis, a non-device chronic...
Microbiological Technician - Stone Brewing - Escondido, CA
You will support the Microbiologist in performing all duties related to the microbiological program including but not limited to processing...
BIND&MODIFY: a long-range method for single-molecule mapping of chromatin...
Epigenetic modifications of histones are associated with development and pathogenesis of disease. Existing approaches cannot provide insights into long-range interactions and...
A translatome-transcriptome multi-omics gene regulatory network reveals the...
Maize is one of the most important crops worldwide. Although sophisticated maize gene regulatory networks have been constructed for functional genomics and phenotypic...
CRISPR screens identify gene targets at breast cancer risk loci
Genome-wide association studies have identified > 200 loci associated with breast cancer risk. The majority of candidate causal variants are in non-coding regions and likely...
The shaky foundations of simulating single-cell RNA sequencing data
With the emergence of hundreds of single-cell RNA-sequencing datasets, the number of computational tools to analyze aspects of the generated data has grown rapidly. As a...