• Annotation of tandem mass spectrometry data using stochastic neural networks in shotgun proteomics

    12 days ago - By Oxford Journals

    AbstractMotivationThe discrimination ability of score functions to separate correct from incorrect peptide-spectrum matches in database-searching-based spectrum identification are hindered by many superfluous peaks belonging to unexpected fragmentation ions or by the lacking peaks of anticipated fragmentation ions.ResultsHere, we present a new method, called BoltzMatch, to learn score functions using a particular stochastic neural networks, called restricted Boltzmann machines, in order to enhance their discrimination ability. BoltzMatch learns chemically explainable patterns among peak...
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