• ThETA: Transcriptome-driven Efficacy estimates for gene-based TArget discovery

    4 days ago - By Oxford Journals

    AbstractSummaryEstimating efficacy of gene target-disease associations is a fundamental step in drug discovery. An important data source for this laborious task is RNA expression, which can provide gene-disease associations on the basis of expression fold change and statistical significance. However, the simply use of the log fold change can lead to numerous false positive associations. On the other hand, more sophisticated methods that utilize gene co-expression networks do not consider tissue specificity. Here we introduce ThETA (Transcriptome-driven Efficacy estimates for gene-based...
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