• The origin of genomic N 6 -methyl-deoxyadenosine in mammalian cells

    4 days ago - By ACS Division of Biological Chemistry

    Nature Chemical Biology, Published online: 23 March 2020; doi:10.1038/s41589-020-0504-2 A metabolic labeling method reveals that genomic N6-methyl-deoxyadenosine in mammalian cell lines originates not from direct methylation in DNA, but from a misincorporation of the metabolite of ribo-N6-methyladenosine.
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  • An aminoacylation ribozyme evolved from a natural tRNA-sensing T-box riboswitch

    4 days ago - By ACS Division of Biological Chemistry

    Nature Chemical Biology, Published online: 23 March 2020; doi:10.1038/s41589-020-0500-6 The authors develop a ribozyme, Tx2.1, that is capable of aminoacylating tRNA with specificity for the anticodon from directed evolution of a T-box riboswitch. Tx2.1 could be used to charge non-natural amino acids in an in vitro translation system.
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