• Screening novel drug candidates for Alzheimer's disease by an integrated network and transcriptome analysis

    22 days ago - By Oxford Journals

    AbstractMotivationAlzheimer's disease is a serious degenerative brain disease and the most common cause of dementia. The current available drugs for AD provide symptomatic benefit, but there is no effective drug to cure the disease. The emergence of large-scale genomic, pharmacological data provides new opportunities for drug discovery and drug repositioning as a promising strategy in searching novel drug for AD.ResultsIn this study, we took advantage of our increasing understanding based on systems biology approaches on the pathway and network levels and perturbation datasets from the...
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