• Effect of iron addition on mAb productivity and oxidative stress in CHO culture

    10 days ago - By Wiley

    Abstract
    Trace metals play a critical role in the development of media used for the production of therapeutic proteins. Iron has been shown to enhance the productivity of monoclonal antibodies during Chinese hamster ovary cell culture. However, the redox activity and pro-oxidant behavior of iron may also contribute towards the production of reactive oxygen species. In this work, we aim to clarify the influence of trace iron by examining the relationship between iron supplementation to culture media, mAb productivity and glycosylation, and oxidative stress interplay within the cell...
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