• Structures of the TetR‐like transcription regulator RcdA alone and in complexes with ligands

    7 days ago - By Wiley

    ABSTRACT
    RcdA is a helix-turn-helix transcriptional regulator belonging to the TetR family. The protein regulates the transcription of curlin subunit gene D, the master regulator of biofilm formation. Moreover, it was predicted that it might be involved in the regulation of up to 27 different genes. However, an effector of RcdA and the environmental conditions which trigger RcdA action remain unknown. Herein, we report the first crystal structures of RcdA in complexes with ligands, trimethylamine N-oxide and trisaminomethane , which might serve as RcdA effectors. Based on these structures...
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