• The wind of change in the management of autosomal dominant polycystic kidney disease in childhood

    1 month ago - By Springer

    Abstract
    Significant progress has been made in understanding the genetic basis of autosomal dominant polycystic kidney disease , quantifying disease manifestations in children, exploring very-early onset ADPKD as well as pharmacological delay of disease progression in adults. At least 20% of children with ADPKD have relevant, yet mainly asymptomatic disease manifestations such as hypertension or proteinuria (in line with findings in adults with ADPKD, where hypertension and cardiovascular damage precede decline in kidney function). We propose an algorithm for work-up and management based...
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