• BMP‐2/TGF‐β1 gene insertion into ligament‐derived stem cells sheet promotes tendon‐bone healing in a mouse

    7 days ago - By Wiley

    Abstract
    Bone morphogenetic protein-2 and transforming growth factor-β1 reportedly induce the osteogenic and tenogenic differentiation of anterior cruciate ligament -derived stem cells , respectively. However, few studies have investigated the effect of BMP-2/TGF-β1 on the differentiation of LDSC. We developed a BMP-2/TGF-β1 gene insertion into an LDSC cell sheet that promotes tendon-bone healing in a mouse ACL reconstruction model..
    CD34+ LDSCs were isolated from human ACL stump tissues, virally transduced to express BMP-2 or TGF-β1, and then embedded within cell sheets. All mice...
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