• MCRL: using a reference library to compress a metagenome into a nonredundant list of sequences, considering viruses as a case study

    14 days ago - By Oxford Journals

    AbstractMotivationMetagenomes offer a glimpse into the total genomic diversity contained within a sample. Currently, however, there is no straightforward way to obtain a nonredundant list of all putative homologs of a set of reference sequences present in a metagenome.ResultsTo address this problem, we developed a novel clustering approach called “metagenomic clustering by reference library” , where a reference library containing a set of reference genes is clustered with respect to an assembled metagenome. According to our proposed approach, reference genes homologous to similar sets of...
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