• PhyloCorrelate: inferring bacterial gene-gene functional associations through large-scale phylogenetic profiling

    15 days ago - By Oxford Journals

    AbstractMotivationStatistical detection of co-occurring genes across genomes, known as “phylogenetic profiling”, is a powerful bioinformatic technique for inferring gene-gene functional associations. However, this can be a challenging task given the size and complexity of phylogenomic databases, difficulty in accounting for phylogenetic structure, inconsistencies in genome annotation, and substantial computational requirements.ResultsWe introduce PhyloCorrelate-a computational framework for gene co-occurrence analysis across large phylogenomic datasets. PhyloCorrelate implements a variety...
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