• Human papillomavirus integration signature in cervical lesions: identification of MACROD2 gene as HPV hot spot integration site

    5 days ago - By Springer

    High-risk HPV is clearly associated with cervical cancer. Integration of HPV DNA into the host genome is considered a key event in driving cervical carcinogenesis. However, the mechanism on how HR-HPV integration influences the host genome structure has remained enigmatic.
    In our study, 25 DNA samples including 11 from fresh-frozen cervical carcinomas and 14 from fresh-frozen high-grade squamous intraepithelial lesion were detected using the method of HPV capture combined with next generation sequencing.
    We calculated the frequency in each viral gene or...
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