• Impact of miR-200b and miR-495 variants on the risk of large-artery atherosclerosis stroke

    9 days ago - By Springer

    Abstract
    Single-nucleotide polymorphisms of microRNAs may alter miRNA transcription, maturation and target specificity, thus affecting stroke susceptibility. We aimed to investigate whether miR-200b and miR-495 SNPs may be associated with ischemic stroke risk and further explore underlying mechanisms including related genes and pathways. MiR-200b rs7549819 and miR-495 rs2281611 polymorphisms were genotyped among 712 large-artery atherosclerosis stroke patients and 1,076 controls in a case-control study. Bioinformatic analyses were performed to explore potential association of miR-200b/495...
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