• Inferring TF activities and activity regulators from gene expression data with constraints from TF perturbation data

    6 days ago - By Oxford Journals

    AbstractMotivationThe activity of a transcription factor in a sample of cells is the extent to which it is exerting its regulatory potential. Many methods of inferring TF activity from gene expression data have been described, but due to the lack of appropriate large-scale datasets, systematic and objective validation has not been possible until now.ResultsWe systematically evaluate and optimize the approach to TF activity inference in which a gene expression matrix is factored into a condition-independent matrix of control strengths and a condition-dependent matrix of TF activity levels...
    Read more ...