• The genes for sensory perception of sound should be considered in gene diagnosis of congenital sensorineural hearing loss and microtia

    9 days ago - By Springer

    Abstract
    Congenital sensorineural hearing loss and microtia are development-related diseases, sharing some factors and affecting children's hearing. However, genetic tests only focus on CSHL. We try to identify the common molecular mechanism of CSHL and microtia as candidates combining gene diagnosis biomarkers. Whole-exon sequencing , Sanger sequencing, qPCR, and bioinformatics analyses were performed in microtia family , family two, whose proband suffered from microtia and CSHL , five microtia, and four CSHL individuals, respectively. We found that 40% microtia and 40% CSHL relevant...
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