• An RNAi-independent role of AP1-like stress response factor Pap1 in centromere and mating-type silencing in Schizosaccaromyces pombe

    1 month ago - By Journal of Biosciences

    Abstract
    Gene silencing in S. pombe occurs by heterochromatin formation at the centromere , mating-type and telomere loci. It is mediated by silencing factors including Swi6, Clr1-4, Rhp6 and Polα. RNAi pathway also plays a role in establishment of silencing at the mat and cen loci. Recently, the stress response factors, Atf1 and Pcr1were shown to play an RNAi-independent role in silencing at the mat3 locus through a cis -acting Atf1-binding site located within the repression element REIII and recruitment of the silencing factors Clr3 and Clr6. Another cis -acting site, named repression...
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