• PCAmatchR: a flexible R package for optimal case-control matching using weighted principal components

    10 days ago - By Oxford Journals

    AbstractSummaryA concern when conducting genome-wide association studies is the potential for population stratification, i.e. ancestry based genetic differences between cases and controls, that if not properly accounted for, could lead to biased association results. We developed PCAmatchR as an open source R package for performing optimal case-control matching using principal component analysis to aid in selecting controls that are well matched by ancestry to cases. PCAmatchR takes user supplied PCA outputs and selects matching controls for cases by utilizing a weighted Mahalanobis...
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