• DNA methylation from bacteria and microbiome using nanopore technology

    8 days ago - By Phys

    Bacterial DNA methylation occurs in diverse sequence contexts and plays important functional roles in cellular defense and gene regulation. An increasing number of studies have reported that bacterial DNA methylation has important roles affecting clinically relevant phenotypes such as virulence, host colonization, sporulation, biofilm formation, among others. Bacterial methylomes contain three primary forms of DNA methylation: N6-methyladenine , N4-methylcytosine and 5-methylcytosine. The widely used bisulfite sequencing for DNA methylation mapping in mammalian genomes are not effective at...
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