• Inferring perturbation profiles of cancer samples

    11 days ago - By Oxford Journals

    AbstractMotivationCancer is one of the most prevalent diseases in theworld. Tumors arise due to important genes changing their activity, e.g., when inhibited or over-expressed. But these gene perturbations are difficult to observe directly. Molecular profiles of tumors can provide indirect evidence of gene perturbations. However, inferring perturbation profiles from molecular alterations is challenging due to error-prone molecular measurements and incomplete coverage of all possible molecular causes of gene perturbations.ResultsWe have developed a novel mathematical method to analyze...
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