• Prognostic value of TP53 co-mutation status combined with EGFR mutation in patients with lung adenocarcinoma

    1 month ago - By Springer

    Abstract
    Purpose
    TP53/EGFR co-mutation has been reported to affect the efficacy of epidermal growth factor receptor tyrosine kinase inhibitors in lung adenocarcinoma. However, its impact on survival is unclear. In this analysis, we explored the prognostic effect of TP53/EGFR co-mutation in LUAD.
    Methods
    Clinical data and transcriptome sequencing of LUAD patients with matched genomic data were downloaded from the Cancer Genome Atlas database for overall survival analysis. Differential expression genes were recognized by R software and bioconductor package. Clusterprofiler was used for...
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