• Sperm DNA methylation epimutation biomarker for paternal offspring autism susceptibility

    15 days ago - By Springer

    Abstract
    Background
    Autism spectrum disorder has increased over tenfold over the past several decades and appears predominantly associated with paternal transmission. Although genetics is anticipated to be a component of ASD etiology, environmental epigenetics is now also thought to be an important factor. Epigenetic alterations, such as DNA methylation, have been correlated with ASD. The current study was designed to identify a DNA methylation signature in sperm as a potential biomarker to identify paternal offspring autism susceptibility.
    Methods and results
    Sperm samples were obtained...
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