• The HiFi difference - haplotype phasing in genome assembly

    1 month ago - By Pacific Biosciences

    Most higher organisms are diploid, meaning that each cell carries in its nucleus two copies of the individual's genome, one from its mother and one from its father. Accurately separating and assembling these two copies, or haplotypes, has challenged the genomics community because the two copies are very similar to each other , but not identical - if they were, your mother and father would look the same! Accurate and contiguous information about these small differences over extended genomic regions is needed to separate, or phase, the two haplotypes. Because short-read sequencing cannot...
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