• The HiFi Sequencing Advantage for Metagenome Assembly

    1 month ago - By Pacific Biosciences

    Assembly and binning of metagenome data are the first steps in many metagenomics analysis pipelines, and with good reason. Metagenome assembled genomes and circularized MAGs allow recovery of complete genes and operons, thereby improving predictions of metabolic capacities. MAGs also provide information about gene synteny and enable better taxonomic profiling. However, as discussed in a recent review by Chen et. al. draft MAGs with poor completeness or high contamination can lead to incorrect conclusions.
    One way to improve assembly completeness and contiguity is to use long-read...
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