• Mapping DEHP to the adverse outcome pathway network for human female reproductive toxicity

    9 days ago - By Springer

    Abstract
    Adverse outcome pathways and AOP networks are tools for mechanistic presentation of toxicological effects across different levels of biological organization. These tools are used to better understand how chemicals impact human health. In this study, a four-step workflow was used to derive the AOP network of human female reproductive toxicity from five AOPs available in the AOP-Wiki and ten AOPs obtained from the literature. Standard network analysis identified key events that are point of convergence and divergence, upstream and downstream KEs, and bottlenecks across the network...
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