• Direct Phased Genome Assembly Using Nighthawk on HiFi Reads

    11 days ago - By Pacific Biosciences

    By Zev Kronenberg, Senior Engineer of Bioinformatics at PacBio
    Since the introduction of HiFi reads the community has embraced these long and highly accurate reads for human genome assembly and paralog resolution. At PacBio, the assembly team is working to build on the accuracy of HiFi data for direct phasing during assembly.
    Figure 1. The PacBio assembly team. From left to right, James Drake, Zev Kronenberg , Derek Barnett , Chris Dunn, and Ivan Sović
    In diploid organisms, phasing an assembly means separating the maternally and paternally inherited copies of each chromosome, known as...
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